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Reprod Biol Endocrinol. 2009 Oct 27;7:120. doi: 10.1186/1477-7827-7-120.
The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats.
Topo E, Soricelli A, D'Aniello A, Ronsini S, D'Aniello G.
Source

1Stazione Zoologica Anton Dohrn, 80121, Villa Comunale, 80121, Napoli, Italy. enza.topo@szn.it
Abstract
BACKGROUND:

D-aspartic acid is an amino acid present in neuroendocrine tissues of invertebrates and vertebrates, including rats and humans. Here we investigated the effect of this amino acid on the release of LH and testosterone in the serum of humans and rats. Furthermore, we investigated the role of D-aspartate in the synthesis of LH and testosterone in the pituitary and testes of rats, and the molecular mechanisms by which this amino acid triggers its action.
METHODS:

For humans: A group of 23 men were given a daily dose of D-aspartate (DADAVIT) for 12 days, whereas another group of 20 men were given a placebo. For rats: A group of 10 rats drank a solution of either 20 mM D-aspartate or a placebo for 12 days. Then LH and testosterone accumulation was determined in the serum and D-aspartate accumulation in tissues. The effects of D-aspartate on the synthesis of LH and testosterone were gauged on isolated rat pituitary and Leydig cells. Tissues were incubated with D-aspartate, and then the concentration (synthesis) of LH and cGMP in the pituitary and of testosterone and cAMP in the Leydig cells was determined.
RESULTS:

In humans and rats, sodium D-aspartate induces an enhancement of LH and testosterone release. In the rat pituitary, sodium D-aspartate increases the release and synthesis of LH through the involvement of cGMP as a second messenger, whereas in rat testis Leydig cells, it increases the synthesis and release of testosterone and cAMP is implicated as second messenger. In the pituitary and in testes D-Asp is synthesized by a D-aspartate racemase which convert L-Asp into D-Asp. The pituitary and testes possesses a high capacity to trapping circulating D-Asp from hexogen or endogen sources.
CONCLUSION:

D-aspartic acid is a physiological amino acid occurring principally in the pituitary gland and testes and has a role in the regulation of the release and synthesis of LH and testosterone in humans and rats.

Hey

Are bulgarian split style good alternative to barbell

i.e. barbell squats - dumbell bulgarian split squats

RDL - bulgarian split RDL - one leg on box behind and aim for a single leg RDL with dumbbell

bulgarian split calf raises - same thing one leg behind and one leg calf raise on floor dumbbell

Quote from: LBSS on December 13, 2012, 03:03:26 pm

Quote from: vag on December 13, 2012, 02:07:13 pm

Quote from: LBSS on December 13, 2012, 01:54:14 pm

my brother got arrested for robbery last night and is in jail. 

dafuq???
How old , what kind of robbery , why would he do that?
Not being indiscreet , don't answer if its personal...

don't know particulars but he was surely stealing whatever it was to buy drugs. my youngest brother is mentally ill and a hardcore drug addict. it's a very sad state of affairs when i'm relieved that he's in jail. deeply sad, too, obviously. but that's a general feeling, not specific to him being in jail.

There is no problem that is too big to be solved.  I know what he is going through.  And he needs to find somethign in life that he is passionate about that will fill the void that he has, and drugs obviously is not the answer.